I've been to Italy so many times over the years and Rome is a city I've spent a ton of time both personally and professionally. Here are the few places I would recommend while in town
I've been many times and this is always an icon that must be visited
Colosseum, Rome | Tickets & Tours - 2024 - Viator
This is one I have not seen yet because the last time I visited the Vatican, it was closed. Another icon worth the visit