The Best Supplements for EDS & Hypermobility: What Helps and Why

Vitamin C is one of the most recommended supplements for people with Ehlers-Danlos Syndrome (EDS), especially the hypermobile type (hEDS). Why? Because Vitamin C is essential for collagen synthesis, which directly impacts joint strength, skin elastic... 

People with EDS often experience fragile skin, slow healing, and joint instability—and while it doesn’t "fix" faulty collagen, Vitamin C can help the body maximize what it has and support healthy tissue repair.

Magnesium is a critical mineral for people with hypermobility spectrum disorders and EDS, known for its role in muscle relaxation, nerve signaling, pain modulation, and even collagen production. 

Many with EDS are magnesium deficient without realizing it—leading to muscle cramps, fatigue, anxiety, and sleep problems. 

By supporting nervous system regulation, magnesium also helps ease symptoms related to dysautonomia, POTS, and chronic stress—all common in the EDS community.

Vitamin D plays a foundational role in bone health, muscle function, and immune resilience—all essential for managing Ehlers-Danlos Syndrome, where joint instability and poor healing are common. Research shows many people with EDS are vitamin D defic... 

Pairing Vitamin D with Vitamin K₂ (especially MK‑7) helps ensure calcium is properly directed into bones—not soft tissues—making this combo ideal for those needing structural support without calcification risks.

Vitamin B₁₂ is a critical nutrient for people with Ehlers-Danlos Syndrome, especially those experiencing chronic fatigue, dizziness, numbness, or cognitive fog. B₁₂ supports nerve function, red blood cell production, and brain clarity—which is especi... 

Many with EDS may have absorption issues (especially if they have IBS or take certain medications), making B₁₂ deficiency more common than realized. Supplementing with methylated B₁₂ (methylcobalamin) is often recommended for better bioavailability.

Iron is a cornerstone mineral for oxygen transport, cellular energy production, and immune resilience—all crucial for managing life with Ehlers-Danlos Syndrome. 

Many people with EDS experience iron deficiency or borderline anemia due to gut absorption issues, heavy periods, or dietary restrictions, often without knowing it. Low iron can lead to fatigue, brain fog, shortness of breath, palpitations, and incre...

Folate, or Vitamin B₉, is essential for cell repair, DNA synthesis, and methylation—a biochemical process that impacts everything from energy metabolism to connective tissue health. For people with hypermobility disorders like EDS, folate plays a sub... 

If you have the MTHFR gene variant, which is common in the neurodivergent and EDS communities, your body may struggle to convert folic acid into its usable form. That’s why methylated folate (like L‑5‑MTHF) is often recommended.

 For people with hypermobile Ehlers-Danlos Syndrome (hEDS), joint instability, popping, and early degeneration are common. Glucosamine and Chondroitin are two of the most widely studied supplements for joint health and cartilage protection—especially ...

For people with Ehlers-Danlos Syndrome (EDS) and chronic fatigue, NAD (Nicotinamide Adenine Dinucleotide) is emerging as a powerful supplement target. NAD is essential for cellular energy production, DNA repair, and mitochondrial resilience—areas tha... 

NAD precursors like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) help the body naturally boost NAD+ levels, fueling mitochondria and supporting deep cellular healing. Many people report increased mental clarity, stamina, reduced in...