I'm based in North America so I have the most familiarity with this continent's nonprofit offerings. If you'd like to see others, let me know!
Global nonprofits are highly needed to mitigate the ongoing effects of colonization, imperialism, and the repercussions of the Transatlantic Enslavement.
Most of these places also accept donations, but not all! They are just fantastic resources about the types of work taking place all around us, all the time.